The most famous 4 x 4 magic square is the so-called Melancholia magic square. In 1514, Albrecht Dürer used the square in his engraving Melancholie which depicts the indecision of the intellectual. The two numbers, 15 and 14, in the centre of the bottom row date the engraving.
This image above I have discussed before in this website. It is also in the legend on the right hand side of this web page.